"medicine that reduces fever," 1680s, from French fébrifuge, literally "driving fever away," from Latin febris (see fever) + fugare "cause to flee, put to flight, drive off, chase away, rout," also used in reference to banishment and exile, derived verb from fuga "flight," from PIE *bhug-a-, suffixed form of root *bheug- (1) "to flee" (see fugitive (adj.)).